Salicylanilides and Their Anticancer Properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00132228" target="_blank" >RIV/00216224:14160/23:00132228 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1422-0067/24/2/1728" target="_blank" >https://www.mdpi.com/1422-0067/24/2/1728</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms24021728" target="_blank" >10.3390/ijms24021728</a>
Alternative languages
Result language
angličtina
Original language name
Salicylanilides and Their Anticancer Properties
Original language description
Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/beta-catenin, mTORC1, STAT3, NF-kappa B and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1661-6596
Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
1-22
UT code for WoS article
000914982800001
EID of the result in the Scopus database
2-s2.0-85146768411