Anticancer Activity of Artemisinin and its Derivatives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098045" target="_blank" >RIV/00216224:14110/17:00098045 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.21873/anticanres.12046" target="_blank" >http://dx.doi.org/10.21873/anticanres.12046</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12046" target="_blank" >10.21873/anticanres.12046</a>

Result language

angličtina

Original language name

Anticancer Activity of Artemisinin and its Derivatives

Original language description

Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G0/G1 phase, induction of apoptosis and inhibition of angiogenesis. Safety studies have shown no evident toxicity and low incidence of adverse effects. ARTs potential to inhibit growth of solid tumours suggests their application in a neoadjuvant therapy. Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and glioma cancer cells, proposing the use of ARTs also in combination anticancer therapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

11

Country of publishing house

GR - GREECE

Number of pages

9

Pages from-to

5995-6003

UT code for WoS article

000416143900010

EID of the result in the Scopus database

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