The anticancer properties of harmine and its derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F25%3A10486002" target="_blank" >RIV/00216208:11150/25:10486002 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/25:10486002
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MOY~8PIrg8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=MOY~8PIrg8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11101-024-09978-0" target="_blank" >10.1007/s11101-024-09978-0</a>
Alternative languages
Result language
angličtina
Original language name
The anticancer properties of harmine and its derivatives
Original language description
This review aims to provide information about the anticancer potential of harmine, a beta-carboline alkaloid that was initially isolated in 1847 from the seeds and roots of Peganum harmala L. Various studies have revealed that it possesses a wide range of therapeutic qualities, including anti-inflammatory, antibacterial, antiviral, antidiabetic, and, most notably, anticancer effects. This review discusses the anticancer capabilities of harmine and its derivatives against malignancies such as breast cancer, lung cancer, gastric cancer, colon cancer, glioblastoma, neuroblastoma, liver cancer, pancreatic cancer and thyroid cancer. Harmine uses mechanisms such as apoptosis and angiogenesis inhibition to fight cancer cells. It also influences the cell cycle by inhibiting specific cyclin-dependent kinases and slowing tumor cell proliferation. Synergistic effects have also been observed when harmine is used in combination with other anticancer medications. Harmine has the potential to be a potent anticancer medication that can help in the fight against cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytochemistry Reviews
ISSN
1568-7767
e-ISSN
1572-980X
Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
30
Pages from-to
1535-1564
UT code for WoS article
001314852800002
EID of the result in the Scopus database
2-s2.0-85204352606