Alginate/chitosan hydrogel particles for site-specific thymol delivery to the colon

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00134102" target="_blank" >RIV/00216224:14160/23:00134102 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Alginate/chitosan hydrogel particles for site-specific thymol delivery to the colon
Original language description
This work aimed to formulate composite hydrogel particles based on two oppositely charged polymers, sodium alginate, and chitosan, prepared by external ion gelation. The dosage form formulation as a self-emulsifying system (SES) carrier was targeted to deliver the insoluble drug thymol to the GIT distal parts. The impact of several formulation variables (the proportional amount of sodium tripolyphosphate and sodium alginate, a type of chitosan, and the amount of incorporated SES on morphological properties, swelling properties, thymol content, and in vitro dissolution profiles over 6 hours were investigated. The most prolonged thymol release was ensured using a higher ratio of tripolyphosphate to sodium alginate and primarily with a higher incorporated SES amount. However, a deeper study on possible use in treating intestinal inflammations is necessary.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-03187S" target="_blank" >GA22-03187S: Rational Design of Polysaccharide‐based Particulate Systems for the Delivery of Mucosal Therapeutics with Broad Spectrum of Biological Activities</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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