Development and evaluation of innovative enteric-coated capsules for colon-specific delivery of hydrophilic biomaterials

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00140434" target="_blank" >RIV/00216224:14160/25:00140434 - isvavai.cz</a>

Result on the web

<a href="https://pdf.sciencedirectassets.com/271189/1-s2.0-S0378517324X00198/1-s2.0-S0378517324012250/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEJT%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIFLykREZIkTcu1ZDZUyL8XtIDd%2FMccU4QoX0fh%2ByGzEaAiBwajj2a6F" target="_blank" >https://pdf.sciencedirectassets.com/271189/1-s2.0-S0378517324X00198/1-s2.0-S0378517324012250/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEJT%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJGMEQCIFLykREZIkTcu1ZDZUyL8XtIDd%2FMccU4QoX0fh%2ByGzEaAiBwajj2a6F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2024.124991" target="_blank" >10.1016/j.ijpharm.2024.124991</a>

Result language

angličtina

Original language name

Development and evaluation of innovative enteric-coated capsules for colon-specific delivery of hydrophilic biomaterials

Original language description

Objective: This research aims to design and evaluate an enteric-coated hard capsule dosage form for targeted delivery of biological materials, such as FMT (fecal microbiota transplant) or live microbes, to the distal parts of the GIT. The capsules are designed to be internally protected against destruction by hydrophilic filling during passage through the digestive tract. Methods: Hard gelatin capsules and DRcapsTM capsules based on HPMC and gellan were used to encapsulate a hydrophilic body temperature-liquefying gelatin hydrogel with caffeine or insoluble iron oxide mixture. Different combinations of polymers were tested for the internal (ethylcellulose, Eudragit (R) E, and polyvinyl acetate) and external (Eudragit (R) S, Acryl-EZE (R), and cellacefate) coating. The external protects against the acidic gastric environment, while the internal protects against the liquid hydrophilic filling during passage. Coated capsules were evaluated using standard disintegration and modified dissolution methods for delayed-release dosage forms. Results: Combining suitable internal (ethylcellulose 1.0 %) and external (Eudragit (R) S 20.0 %) coating of DRcapsTM capsules with the wiping and immersion method achieved colonic release times. While most coated capsules met the pharmaceutical requirements for delayed release, one combination stood out. Colonic times were indicated by the dissolution of soluble caffeine (during 120-720 min) measured by the dissolution method, and capsule rupture was indicated by the release of insoluble iron oxide (after 480 min) measured by the disintegration method. This promising result demonstrates the composition's suitability and potential to protect the content until it's released, inspiring hope for the future of colon-targeted delivery systems and its potential for the pharmaceutical and biomedical fields. Conclusion: Innovative and easy capsule coatings offer significant potential for targeted drugs, especially FMT water suspension, to the GIT, preferably the colon. The administration method is robust and not considerably affected by the quantity of internal or external coatings. It can be performed in regular laboratories without specialized individual and personalized treatment equipment, making it a practical and feasible method for drug delivery.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

1873-3476

Volume of the periodical

668

Issue of the periodical within the volume

Neuvedeno

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

15

Pages from-to

1-15

UT code for WoS article

001368962700001

EID of the result in the Scopus database

2-s2.0-85210122726