Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870238" target="_blank" >RIV/62157124:16370/11:43870238 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/03639045.2011.561350" target="_blank" >http://dx.doi.org/10.3109/03639045.2011.561350</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03639045.2011.561350" target="_blank" >10.3109/03639045.2011.561350</a>
Alternative languages
Result language
angličtina
Original language name
Coated hard capsules as the pH-dependent drug transport systems to ileo-colonic compartment
Original language description
Purpose: The aim of this study was to investigate the suitability of hard capsules of different composition (gelatin-G, gelatin coated with hydroxypropyl cellulose-G/HPC, and hypromellose-H) for a coating with aqueous dispersion of pH-dependent syntheticpolymer Eudragit (R) FS (E(FS)) and to evaluate in vitro the coated capsules as transport systems for ileo-colonic drug delivery. Methods: Three sets of hard capsules with increasing coating levels (5-30%) were obtained by Wurster technique. The releaseof model drug (caffeine) from prepared samples was tested using paddle dissolution method with continual pH change (pH 1.2-2 h, 6.8-4 h and 7.5-2 h). Results: During the coating process, no problems occurred and similar suitability of capsules materialsfor E(FS) application was observed in contrast to some published reports. The application of HPC subcoating onto gelatin capsules surface was shown as the redundant step. The samples G/E(FS) 10-15% and H/E(FS) 15-20% with 6 h lag time an
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10222" target="_blank" >NS10222: Microparticle dosage form for theraphy of nonspecific inflammatory bowel diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Development and Industrial Pharmacy
ISSN
0363-9045
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1131-1140
UT code for WoS article
000294862600001
EID of the result in the Scopus database
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