PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00142555" target="_blank" >RIV/00216224:14160/25:00142555 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
PREPARATION OF AMINO-FUNCTIONALIZED THC DERIVATIVES AS POTENTIAL BIOACTIVE COMPOUNDS
Original language description
Tetrahydrocannabinol (THC) is the main psychoactive component of Cannabis sativa and a ligand of the cannabinoid receptors CB1 and CB2. These G-protein-coupled receptors are part of the endocannabinoid system, which regulates a wide array of physiological processes. Although THC and its analogues exhibits a wide range of biological activities through its interaction with cannabinoid receptors, their clinical use is limited by poor water solubility, psychoactive side effects, and insufficient receptor selectivity [2]. Chemical modification of the THC structure represents a promising strategy to overcome these limitations and generate new compounds with improved pharmacokinetic and pharmacodynamic profiles. The introduction of amino group offers multiple advantages: increased solubility, the ability for salt formation, better receptor interaction via hydrogen bonding or electrostatic forces, and access to a broad range of further derivatization.
Czech name
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Czech description
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Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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