Aminopeptidase N: a multifunctional and promising target in medicinal chemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00143705" target="_blank" >RIV/00216224:14160/25:00143705 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra03038b" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/ra/d5ra03038b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d5ra03038b" target="_blank" >10.1039/d5ra03038b</a>
Alternative languages
Result language
angličtina
Original language name
Aminopeptidase N: a multifunctional and promising target in medicinal chemistry
Original language description
Aminopeptidase N (APN) is a zinc metalloproteinase present in almost all types of organisms and has various functions. Many of them are unrelated to its catalytic activity, which is why APN is sometimes classified as a moonlighting enzyme. APN is involved in carcinogenesis and angiogenesis. It also works as an entrance receptor for some coronaviruses and acts as a mediator during skin inflammation. Additionally, APN removes and helps to recycle regulatory proteins including neuropeptides, which is why its inhibitors hold therapeutic potential for a wide range of diseases, making the design and development of such molecules highly desirable. Some of them, such as bestatin or tosedostat, have already been tested as therapeutics with partial success. This article aims to bring an overview of multiple APN functions and implications for various diseases and their inhibitors which have already been prepared, and to suggest areas where the development of inhibitors may be promising in the future.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RSC ADVANCES
ISSN
2046-2069
e-ISSN
2046-2069
Volume of the periodical
15
Issue of the periodical within the volume
32
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
26455-26472
UT code for WoS article
001534076900001
EID of the result in the Scopus database
2-s2.0-105011612473