Aminopeptidase N as a potential drug target

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00133779" target="_blank" >RIV/00216224:14160/23:00133779 - isvavai.cz</a>
Result on the web
<a href="https://sciendo.com/issue/AFPUC/0/0" target="_blank" >https://sciendo.com/issue/AFPUC/0/0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2024-0002" target="_blank" >10.2478/afpuc-2024-0002</a>

Result language
angličtina
Original language name
Aminopeptidase N as a potential drug target
Original language description
Aminopeptidase N (APN) is a broad specificity zinc metallopeptidase with many functions that do not always depend on its enzymatic activity. Among others, it is involved in tumor angiogenesis and metastasizing and also serves as a cellular receptor of some coronaviruses. Some APN inhibitors, such as bestatin or tosedostat, were used or tested as anticancer drugs in the past. Within the past two decades, we have prepared several series of potential APN inhibitors. Some of them reached interesting values of inhibitory activity and were also successfully tested for antiproliferation activity in cancer cell lines. We also performed some QSAR studies with APN inhibitors prepared by us and other authors.
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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