Quaternary Benzo/c/phenantridine alkaloids as inhibitors of dipeptidylpeptidase IV and aminopeptidase N.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F00%3A00000551" target="_blank" >RIV/00064165:_____/00:00000551 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Quaternary Benzo/c/phenantridine alkaloids as inhibitors of dipeptidylpeptidase IV and aminopeptidase N.

Original language description

The inhibitory effect of chelerythrine, sanguinarine, fagaronine andsanguiritrine on the membrane proteases DPP IV and APN is described.Inhibition of these proteases by QBA in serum is suppresed by albumin.To explaine this phenomenon, the mode of QBA binding with albumin has beeninvestigated.Because of well documented role of DPP-IV/CD26 and APN/CD13enzyme activities in the processes of cell activation and differentiation,their inhibitors could be useful tools for fundamental enzymological studiesas well as for future practical applications.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/NK4856" target="_blank" >NK4856: Cytokines,eicosanoids and growth factors in the pathogenesis of primary glomerulonephritides</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Phytotherapy

ISSN

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e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

9

Country of publishing house

XX - stateless person

Number of pages

2

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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