Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12122" target="_blank" >RIV/00216208:11110/12:12122 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/12:00387877
Result on the web
<a href="http://dx.doi.org/10.1016/j.biocel.2012.01.011" target="_blank" >http://dx.doi.org/10.1016/j.biocel.2012.01.011</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity
Original language description
The report analyzes the expression and function of DPP-IV in glioma cells. Variable expression of DPP-IV and homologous proteases fibroblast activation protein, DPP8 and DPP9 was observed in primary cell cultures derived from high-grade gliomas and the overall DPP-IV-like enzymatic activity was negatively associated with their in vitro growth. The DPP-IV positive subpopulation isolated from the primary cell cultures using immunomagnetic separation exhibited slower proliferation, in addition, transfection of the wild as well as the enzymatically inactive mutant DPP-IV resulted in the reduced growth, migration and adhesion in different glioma cell lines in vitro. It also suppressed glioma growth in an orthotopic xenotransplantation mouse model. Microarray analysis of glioma cells with forced DPP-IV expression revealed differential expression of several candidate genes not linked to the tumor suppressive effects of DPP-IV in previous studies with enrichment of genes associated with cell p
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biochemistry & Cell Biology
ISSN
1357-2725
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
738-747
UT code for WoS article
000303558600014
EID of the result in the Scopus database
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