Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00144336" target="_blank" >RIV/00216224:14160/25:00144336 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Isolation of a unique monoterpene diperoxy dimer from Ziziphora clinopodioides subsp. bungeana together with triterpenes with antidiabetic properties
Original language description
Extensive chromatographic separation of a chloroform-soluble fraction led to the isolation of twenty compounds, including a unique monoterpene diperoxy dimer (1). The structures were elucidated by 1D and 2D NMR experiments along with HRMS. Compound 1 was additionally identified by the single crystal X-ray diffraction method. α-Glucosidase inhibitory assay and GLUT4 expression and translocation in C2C12 myotubes were conducted to evaluate antidiabetic potential of selected compounds (1-11). Compounds 7 and 9-11 displayed more potent α-glucosidase inhibitory activity (IC50 45.3-135.3 μM) than acarbose used as a positive control (IC50 264.7 μM), while only pomolic acid (5) increased GLUT4 translocation in C2C12 myotubes in a significant manner.
Czech name
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Czech description
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Project
<a href="/en/project/GA23-04655S" target="_blank" >GA23-04655S: Role of prenylation and glycosylation patterns in anti-inflammatory activity and metabolism of natural phenolic compounds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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