GOLEM V2 BIORELEVANT DISSOLUTION DEVICE: TAPPING THE POTENTIAL IN PROLONGED RELEASE MATRIX TABLETS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00144372" target="_blank" >RIV/00216224:14160/25:00144372 - isvavai.cz</a>
Result on the web
<a href="https://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2024%2F5%2F851.pdf" target="_blank" >https://www.ptfarm.pl/download/?file=File%2FActa_Poloniae%2F2024%2F5%2F851.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.32383/appdr/199377" target="_blank" >10.32383/appdr/199377</a>
Alternative languages
Result language
angličtina
Original language name
GOLEM V2 BIORELEVANT DISSOLUTION DEVICE: TAPPING THE POTENTIAL IN PROLONGED RELEASE MATRIX TABLETS
Original language description
Dynamic biorelevant dissolution devices have become an important part of pharmaceutical research and development. Golem v2 represents such an instrument. The aim of this study was to examine its potential for use in the evaluation of standard hydrophilic, lipophilic, and dual matrices. The effect of the agitation rate was observed. The obtained profiles were assessed based on difference and similarity factors compared with the USP II profiles. Selected kinetic and release mechanism models were used in this study. Hydrophilic matrices differed in modified release excipient hydroxypropylmethylcellulose (10-30%), and apart from the lowest 10% concentration, the profiles were found to be similar to standard dissolution. Lipophilic matrices differed in tablet hardness, which was shown to be a major factor resulting in different profiles. Their Golem v2 profiles were also not similar to the corresponding USP II dissolution profiles, hinting at possible discriminatory differences and intriguing options for erosion-based dosage forms. Similar behavior was observed for the dual-matrix tablets. Different agitation rates yielded similar profiles. Additionally, the pressure and force values were measured using the elements of their own construction. Depending on the volume and agitation rate, the difference pressure ranged from 0.29 +/- 0.04 kPa to 1.66 +/- 0.03 kPa, suggesting values similar to pressure baseline in vivo.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Poloniae Pharmaceutica
ISSN
0001-6837
e-ISSN
2353-5288
Volume of the periodical
81
Issue of the periodical within the volume
5
Country of publishing house
PL - POLAND
Number of pages
17
Pages from-to
851-867
UT code for WoS article
001451272900010
EID of the result in the Scopus database
2-s2.0-85219403799