Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F09%3A00002097" target="_blank" >RIV/62157124:16370/09:00002097 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

Original language description

The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose p

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Drug Development and Industrial Pharmacy

ISSN

0363-9045

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000268879400005

EID of the result in the Scopus database

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