Diffusion Tensor Imaging And Tractography In Autistic, Dysphasic, And Healthy Control Children

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14210%2F19%3A00112323" target="_blank" >RIV/00216224:14210/19:00112323 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/diffusion-tensor-imaging-and-tractography-in-autistic-dysphasic-and-he-peer-reviewed-article-NDT#" target="_blank" >https://www.dovepress.com/diffusion-tensor-imaging-and-tractography-in-autistic-dysphasic-and-he-peer-reviewed-article-NDT#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/NDT.S219545" target="_blank" >10.2147/NDT.S219545</a>

Result language

angličtina

Original language name

Diffusion Tensor Imaging And Tractography In Autistic, Dysphasic, And Healthy Control Children

Original language description

Background: Diffusion tensor imaging (DTI) is a powerful tool for investigating brain anatomical connectivity. The aim of our study was to compare brain connectivity among children with autism spectrum disorders (ASD), developmental dysphasia (DD), and healthy controls (HC) in the following tracts: the arcuate fasciculus (AF), inferior frontal occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), and uncinate fasciculus (UF). Methods: Our sample consisted of 113 children with a mean age 8.7 +/- 2.2 years (77 boys, 36 girls), divided into three subgroups: ASD (n=39), DD (n=36), and HC (n=38). The International Classification of Diseases, 10th ed. was used to make clinical diagnoses. DTI images were collected using a 1.5 T Phillips Achieva MR imaging system. Results: Detailed analyses of fractional anisotropy (FA) revealed significant differences among the ASD, DD, and HC groups in the left AF (p=0.014) and right AF (p=0.001), the left IFOF (p&lt;0.001) and right IFOF (p&lt;0.001), the left ILF (p&lt;0.001) and right ILF (p&lt;0.001), but not in the UF. Post-hoc analyses revealed three patterns of FA differences among the groups: (1) in the right AF, right IFOF, and right ILF, FA was significantly lower in the ASD group compared to the DD and HC groups; however, there was no difference in FA between DD and HC; (2) in the left AF and left IFOF, FA was significantly lower in the ASD than in the HC group, but there were no differences between DD vs HC nor DD vs ASD; and (3) in the left ILF, no difference in FA was seen between ASD and DD, but FA in both was significantly lower than in the HC. Conclusion: Microstructural white matter properties differed between ASD vs DD and HC subjects. The tract where FA impairment in ASD and DD subjects was the most similar was the left ILF.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

50102 - Psychology, special (including therapy for learning, speech, hearing, visual and other physical and mental disabilities);

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychiatric Disease and Treatment

ISSN

1176-6328

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

3 October 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

2843-2852

UT code for WoS article

000489159600002

EID of the result in the Scopus database

2-s2.0-85073530327