v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F01%3A00004455" target="_blank" >RIV/00216224:14310/01:00004455 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

v-Jun and v-Fos proteins induce dedifferentiation of v-myb-transformed monoblasts

Original language description

The fos/jun proto-oncogenes encode for proteins which are components of the AP-1 transcription complex that includes several Fos related and Jun related proteins. The AP-1 was shown to play multiple roles in functional development of hematopoietic precursor cells to mature blood cells. To gain insights into the role of fos/jun in leukemogenicity, we expressed v-fos and v-jun in the line of chicken monoblasts BM2. We found that either v-fos or v-jun-expressing BM2 cells exhibit signs of dedifferentiation. This suggests that oncogenic forms of Jun adn Fos proteins can further enforce v-Myb transformation.

Czech name

—

Czech description

—

Type

D - Article in proceedings

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

<a href="/en/project/GA301%2F01%2F0040" target="_blank" >GA301/01/0040: The Role of Fos and Jun proteins in RA-driven monocytic differentiation</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

The 17th annual meeting on oncogenes

ISBN

—

ISSN

—

e-ISSN

—

Number of pages

1

Pages from-to

171

Publisher name

Foundation for Advanced Cancer Studies, Inc.

Place of publication

Frederick, MD, USA

Event location

Frederick, MD, USA

Event date

Jan 1, 2001

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

—