Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00008669" target="_blank" >RIV/00216224:14330/03:00008669 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
čeština
Original language name
Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
Original language description
c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.
Czech name
Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
Czech description
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Classification
Type
D - Article in proceedings
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Memory in Living Systems
ISBN
80-210-3264-2
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
73
Publisher name
Czechoslovak Biological Society
Place of publication
Brno
Event location
Brno
Event date
Nov 19, 2003
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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