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Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00008669" target="_blank" >RIV/00216224:14330/03:00008669 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    čeština

  • Original language name

    Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

  • Original language description

    c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.

  • Czech name

    Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Memory in Living Systems

  • ISBN

    80-210-3264-2

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

    73

  • Publisher name

    Czechoslovak Biological Society

  • Place of publication

    Brno

  • Event location

    Brno

  • Event date

    Nov 19, 2003

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article