c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00008450" target="_blank" >RIV/00216224:14310/03:00008450 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/03:17033156 RIV/00209805:_____/03:00008071
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts
Original language description
c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for differentiation, proliferation and apoptosis in multiple cell types. In this study, we examined the role of c-Fos and v-Fos proteins in v-myb-transformed BM2 monoblats. We show that while the v-Fos protein prolongs the G0G1 phase of the BM2 cell cycle, c-Fos leaves the cell cycle unaffected and, rather, induces programmed cell death. The apoptosis promoting activity of the c-Fos protein is markedlyenhanced in cells cultivated under serum-free conditions. c-Fos-induced apoptosis occurred in the presence of Bcl-2 and was not dependent on the transcription activation function of the c-Fos protein. No differentiation-promoting activity of the Fos proteins was observed. The effects of Fos proteins on BM2 cells differ from those induced by Jun proteins, suggesting differential roles of individual components of the AP-1 transcription factor in regulation essential cellular processes.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular and Molecular Life Sciences
ISSN
1420-682X
e-ISSN
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Volume of the periodical
60
Issue of the periodical within the volume
12
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
2736-2748
UT code for WoS article
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EID of the result in the Scopus database
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