The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F01%3A00004785" target="_blank" >RIV/00216224:14310/01:00004785 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Reactivity Study on N3, N3-(3-Oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene)thioureas
Original language description
The model compound N3,N3-(3-oxapentan-1,5-diyl)-N1-(2-phenyl-3,4-dihydroquinazolin-4-ylidene) thiourea 1 was synthesized in a one-pot reaction from N1-(2-cyanophenyl) benzamide as reported. It was proved from the computational studies of 1 that the competing nucleophile sites would be the N3 of quinazoline skeleton and sulfur atom. It was found that the 1 undergoes transamination reactions with primary and secondary amines. The compound 1 gives the alkylation reaction at the sulfur atom. The later result was attributed to the hard-soft theory. The model compound 1 reacts with secondary amines in the presence of H2O2 to produce the guanidine derivative by the elimination of the sulfanyl group.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F01%2F1333" target="_blank" >GA203/01/1333: Chalcogen organic compounds - synthesis, transformation and structure elucidation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XXVth Conference of Organic Chemists
ISBN
80-7194-349-5
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
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Publisher name
Publishing House of Pardubice University
Place of publication
Pardubice
Event location
Pardubice
Event date
Jan 1, 2001
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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