Expression of putative mycobacterial glycosyltransferase Rv1526c

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F02%3A00007111" target="_blank" >RIV/00216224:14310/02:00007111 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Expression of putative mycobacterial glycosyltransferase Rv1526c
Original language description
At present, there can be seen a huge prevalence of tuberculosis all over the world. The most serious problem of its treatment arises specially from multidrugs resistant (MDR) forms of Mycobacterium tuberculosis patogen that are not possible to cure by conventional antimycobacterial therapies. Our research is focused on glycosyltransferases (GTs) from M. tuberculosis, enzymes that are responsible for biosynthesis of a cell wall envelope of this pathogen. They build some unique sugar components that playa crucial role in host-pathogen interactions. Using various bioinformatics tools applied to M. tuberculosis genome sequence, genes of some putative GTs were selected and cosmids carrying DNA of these GTs were obtained from Pasteur institute in Paris. Presented contribution is focused on putative rhamnosyltransferase Rv1526c. Generally, the most complicating point in preparation of GTs is low expression of these proteins in soluble form (proteins are toxic for expression host cells, proba
Czech name
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Czech description
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Project
<a href="/en/project/LN00A016" target="_blank" >LN00A016: BIOMOLECULAR CENTER</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
The 18th Biochemical Congress
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
118
Publisher name
Slovenská spoločnosť pre biochémiu a molekulárnu biológiu pri SAV
Place of publication
Slovensko
Event location
September 10 - 13, 2002, Stará Lesná, Slovakia
Event date
Jan 1, 2002
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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