Electrochemical determination of d(GCGAAAGC) hairpin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00008111" target="_blank" >RIV/00216224:14310/03:00008111 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical determination of d(GCGAAAGC) hairpin
Original language description
Hairpins (or hairpin-like structures) may play a major role in expansion events of triplet repeat expansion diseases (X syndrome, Huntington s disease, Friedeich s ataxia). The d(GCGAAGC) fragment has been found in the replication origins of phage fX 174and herpes simplex virus, in a promoter region of an E.coli heat-shock gene, and in rRNA genes. Recently, the structure of d(GCGAAGC) has been determined by NMR spectroscopy and refined using molecular dynamics [1]. For fast and economical determinationof the hairpin in biological materials applicability of voltammetric methods was investigated. On mercury electrodes the d(GCGAAGC) hairpin provides a voltammetric reduction signal (A and C) and an oxidation signal (G). Both signals have been studied bycyclic voltammetry and square wave voltammetry in dependence on pH change, accumulation time, scan rate, and exchange of minihairpin sequences. The elimination voltammetry with linear scan (EVLS) [2-4] in combination with the adsorptive
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
XVII th International Symposium on Bioelectrochemistry and Bioenergetics
ISBN
nebylo uděleno
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
138
Publisher name
The Bioelectrochemical Society
Place of publication
Florence, Italy
Event location
Florence, Italy
Event date
Jun 19, 2003
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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