Structure and Dynamics of RNA K-turn Motifs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00009894" target="_blank" >RIV/00216224:14310/03:00009894 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Structure and Dynamics of RNA K-turn Motifs
Original language description
Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus c
Czech name
Struktura a dynamika RNA KInk-turn motivov
Czech description
Hinge-like RNA motifs occur at conserved positions in the 16S and 23S ribosomal RNAs, as revealed by x-ray crystallography of the 50S subunits of H. marismortui and D. radiodurans and the 30S subunit of T. thermophilus. The conformation of these asymmetric internal loops, called Kink-turns or K-turns, produces sharp, 120-degree bends in both phosphodiester backbones resulting in a V-shaped structure with an acute angle of ca.60 deg. between the RNA helices flanking the motif. In addition, some K-turns are specific binding sites for ribosomal proteins and others take part in RNA-RNA tertiary interactions. We have carried out a set of explicit-solvent Molecular Dynamics (MD) simulations for selected K-turn RNA motifs, including K-turn 38,K-turn 42 and K-turn 58 from the 23S ribosomal RNA of Haloarcula marismortui. The simulations reveal an unprecedented dynamical flexibility, suggesting that K-turn motifs may function as a very flexible internal loops linking rigid helix stems and thus c
Classification
Type
D - Article in proceedings
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/LN00A016" target="_blank" >LN00A016: BIOMOLECULAR CENTER</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
RNA klub
ISBN
—
ISSN
—
e-ISSN
—
Number of pages
1
Pages from-to
21-21
Publisher name
Praha
Place of publication
Praha
Event location
Praha
Event date
Sep 25, 2003
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
—