Study of cytosolic glutathione s-tranferase activity with styrene oxide by electromigration methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010320" target="_blank" >RIV/00216224:14310/04:00010320 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Study of cytosolic glutathione s-tranferase activity with styrene oxide by electromigration methods
Original language description
Styrene-7,8-oxide is an industrial chemical used in the manufacture of epoxy resins; as an intermediate in the preparation of various agricultural chemicals, cosmetics and plastics; and in the processing of textile and fibres. SO is also the major cytochrome P450 metabolite of styrene, used in plastic and resin manufacture. As epoxide, SO is highly reactive and able to undergo reactions with various nucleophilic groups in tissue components, causing radiomimetic effects such as growth inhibition, cytotoxicity and mutagenicity. In addition SO has been classified as carcinogenic in animals and is probably carcinogenic in humans. Its detoxification may occur due to glutathione S-transferase (GST) catalysed conjugation with cytosolic glutathione. As peopleworking in a number of industries are exposed to styrene and SO, it is important to examine the role of glutathione conjugation versus other competing detoxication pathways. Similar studies have often been hampered by the lack of reliable
Czech name
Studium cytosolické GST pomocí elektromigračních metod.
Czech description
jedná se o studium cytosolické GST pomocí elektromigračních metod.
Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F02%2F1447" target="_blank" >GA203/02/1447: Capillary electrochromatography in linear and planar microstructures using polymer beds</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Book of abstract 14 th International Symposium on Capillary Electroseparation Techniques ITP 2004
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
32
Publisher name
Consiglio Nazionale delle Ricerche
Place of publication
Řím
Event location
Řím Itálie
Event date
Sep 12, 2004
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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