Pseudomonas aeruginosa lectins and recognition of host glycans : Structures and thermodynamics

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010506" target="_blank" >RIV/00216224:14310/04:00010506 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Pseudomonas aeruginosa lectins and recognition of host glycans : Structures and thermodynamics
Original language description
Pseudomonas aeruginosa galactose- and fucose-binding (PA-IL and PA-IIL) lectins contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients [1]. The crystal structures of both lectins have been solved in complex with the corresponding monosaccharides [2,3]. Although the two lectins are different in sequence and structure, they display the unusual characteristics to bind carbohydrates through direct interaction via one or two calcium ions. The structures or PA-IIL with a series of different monosaccharides have now been solved and allow for rationalizing the basis of the unusual high specificity of this lectin for fucose, and of the broad range of monosaccharides that can be bound.
Czech name
Lektiny Pseudomonas aeruginosa a a rozpoznávání hostitele: struktura a termodynamika
Czech description
Lektiny Pseudomonas aeruginosa a a rozpoznávání hostitele: struktura a termodynamika

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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