Structural and thermodynamical characterisation between PA-IIL lectin from Pseudomonas aeruginosa and oligosaccharides on cell surface
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010512" target="_blank" >RIV/00216224:14310/04:00010512 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/04:00011118
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Structural and thermodynamical characterisation between PA-IIL lectin from Pseudomonas aeruginosa and oligosaccharides on cell surface
Original language description
Pseudomonas aeruginosa galactose- and fucose-binding (PA-IL and PA-IIL) lectins contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients [1]. The crystal structures of both lectins have been solved in complex with the corresponding monosaccharides [2,3]. Although the two lectins are different in sequence and structure, they display the unusual characteristics to bind carbohydrates through direct interaction via one or two calcium ions. The structures or PA-IIL with a series of different monosaccharides have now been solved and allow for rationalizing the basis of the unusual high specificity of this lectin for fucose, and of the broad range of monosaccharides that can be bound.
Czech name
Strukturní a termodynamická charakterizace interakcí mezi PA-IIL lektinem bakterie Pseudomonas aeruginosa a oligosacharidy na povrchu buněk
Czech description
Strukturní a termodynamická charakterizace interakcí mezi PA-IIL lektinem bakterie Pseudomonas aeruginosa a oligosacharidy na povrchu buněk
Classification
Type
D - Article in proceedings
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
The 8th Workshop of Biochemists and Molecular Biologists
ISBN
80-210-3321-5
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
20
Publisher name
Masarykova univerzita
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2004
Type of event by nationality
CST - Celostátní akce
UT code for WoS article
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