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Structural and thermodynamical characterisation between PA-IIL lectin from Pseudomonas aeruginosa and oligosaccharides on cell surface

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010512" target="_blank" >RIV/00216224:14310/04:00010512 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/04:00011118

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Structural and thermodynamical characterisation between PA-IIL lectin from Pseudomonas aeruginosa and oligosaccharides on cell surface

  • Original language description

    Pseudomonas aeruginosa galactose- and fucose-binding (PA-IL and PA-IIL) lectins contribute to the virulence of this pathogenic bacterium, which is a major cause of morbidity and mortality in cystic fibrosis patients [1]. The crystal structures of both lectins have been solved in complex with the corresponding monosaccharides [2,3]. Although the two lectins are different in sequence and structure, they display the unusual characteristics to bind carbohydrates through direct interaction via one or two calcium ions. The structures or PA-IIL with a series of different monosaccharides have now been solved and allow for rationalizing the basis of the unusual high specificity of this lectin for fucose, and of the broad range of monosaccharides that can be bound.

  • Czech name

    Strukturní a termodynamická charakterizace interakcí mezi PA-IIL lektinem bakterie Pseudomonas aeruginosa a oligosacharidy na povrchu buněk

  • Czech description

    Strukturní a termodynamická charakterizace interakcí mezi PA-IIL lektinem bakterie Pseudomonas aeruginosa a oligosacharidy na povrchu buněk

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    The 8th Workshop of Biochemists and Molecular Biologists

  • ISBN

    80-210-3321-5

  • ISSN

  • e-ISSN

  • Number of pages

    1

  • Pages from-to

    20

  • Publisher name

    Masarykova univerzita

  • Place of publication

    Brno

  • Event location

    Brno

  • Event date

    Jan 1, 2004

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article