Determination of azidothymidine - an antiproliferative and virostatic drug by square wave voltammetry

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00011177" target="_blank" >RIV/00216224:14310/04:00011177 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/04:00104697

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Determination of azidothymidine - an antiproliferative and virostatic drug by square wave voltammetry

Original language description

The azido-deoxythymidine (AZT, Zidovudine) is an antiproliferative and virostatic drug widely used in human immunodeficiency virus type 1 (HIV-1) infection treatment. With respect to side effects of high doses and a short half-life of AZT, a fast and simple detection method for this agent could be helpful. The aim of our study was to determine AZT levels in natural samples (urine, serum, whole blood, and cell cultures, such as the HaCaT line of keratinocytes) without their mineralization and/or purification, by means of electrochemical methods using hanging mercury drop electrode (HMDE). On this electrode, AZT undergoes irreversible reduction at the peak potential near Ep -1.1 V (vs. Ag/AgCl/3M KCl). Reduction AZT signals were measured by cyclic voltammetry (CV), differential pulse voltammetry (DPV), square wave voltammetry (SWV), and constant current chronopotentiometric stripping analysis (CPSA). In phosphate buffer (pH 8) the SWV yielded the best AZT signal with the detection limit

Czech name

Stanovení azidothymidinu- antiproliferačního a virostatického léku pomocí square wave voltametrie

Czech description

Stanovení azidothymidinu-antiproliferačního a virostatického léku pomocí square wave voltametrie

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electroanalysis

ISSN

1040-0397

e-ISSN

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Volume of the periodical

2004

Issue of the periodical within the volume

16

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

224-230

UT code for WoS article

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EID of the result in the Scopus database

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