Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00013140" target="_blank" >RIV/00216224:14310/05:00013140 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Genotoxic activity of a technical toxaphene mixture and its photodegradation products in the SOS genotoxicity tests
Original language description
Toxaphene (CAS No. 800-35-2) is a complex mixture of several hundred components, that was used worldwide primarily as an agricultural pesticide with insecticide effects in the second half of the 20th century. In vitro investigations of genotoxicity and mutagenicity of toxaphene were in literature generally described, but they provided somewhat equivocal results. We re-evaluated the technical toxaphene in two prokaryotic systems. The SOS Chromotest showed high sensitivity to toxaphene. Three highest concentrations (40, 20 and 10 mg/l) were clearly positive and the dose-response effect was evident. In the umuC assay at concentrations from 2.5 to 40.0 mg/l, a dose-dependent increase in genotoxic activity was observed, but these results were found to be insignificant. Genotoxicity of toxaphene and its photodegradation products was also examined in this study after UV irradiation (3-6-9 h) at concentrations from 7.5 to 60.0 mg/l. Irradiated solution of technical toxaphene after 3 h showed n
Czech name
Genotoxický potenciál toxafenu a jeho fotodegradačních produktů
Czech description
Toxaphene
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
DN - Environmental impact on health
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA525%2F03%2F0367" target="_blank" >GA525/03/0367: Ecotoxicology of persistent organic environmental pollutants</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
ISSN
1383-5718
e-ISSN
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Volume of the periodical
2005
Issue of the periodical within the volume
565
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
113-120
UT code for WoS article
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EID of the result in the Scopus database
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