Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014596" target="_blank" >RIV/00216224:14310/05:00014596 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genomic imbalance detected in glioblastoma multigorme using high-resolution comparative genomic hybridization

Original language description

Glioblastoma multiforme (GBM) is the most common form of primary neoplasm occurring in the central nervous system of adults. The tumour can develop from a low-degree or anaplastic astrocyte secondary glioblastoma, but more frequently it manifests itselfwith a short clinical anamnesi as primary glioblastoma. Cytogenetic diagnostic methods form an integral part glioblastoma diagnostics, however, conventional cytogenetics has been unable to identify consistent chromosomal aberrations in this group of tumours. Thus, more advanced molecular cytogenetic approaches are required to study the relationship between chromosomal instability and patient prognosis. The aim of this study was to screen for chromosomal imbalances in GBM by CGH and modified HR-CGH. Aimwas to determine chromosomal changes on primary tumours and evaluate intratumoral genetic heterogenity by comparing gains and losses of chromosomes in central and peripheral areas of tumours. In this study, chromosomal abnormalities in 22

Czech name

Abnormality chromozomů detegované u multiformního glioblastomu pomocí techniky komparativní genomové hybridizace s vysokým rozlišením

Czech description

Práce se zabývá výskytem specifických chromozomových abnormalit u mozkového nádoru multiformního glioblastomu, které byly studovány pomocí techniky komparativní genomové hybridizace s vysokým rozlišením.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/OC%20B19.001" target="_blank" >OC B19.001: Gene Diagnostics and Therapy of Multiform Glioblastoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromosome Research

ISSN

9067-3849

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

87

UT code for WoS article

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EID of the result in the Scopus database

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