Toxicological aspects of flavonoid interaction with biomacromolecules
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00015538" target="_blank" >RIV/00216224:14310/06:00015538 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/06:00103428 RIV/00216208:11310/06:10057
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Toxicological aspects of flavonoid interaction with biomacromolecules
Original language description
Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human bodyshould be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. The oxidation si
Czech name
Toxikologické aspekty interakcí flavonoidů s biomakromolekulami
Czech description
Toxikologické aspekty interakcí flavonoidů s biomakromolekulami
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinol. Lett.
ISSN
0172-780X
e-ISSN
—
Volume of the periodical
27
Issue of the periodical within the volume
suppl2
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
14-17
UT code for WoS article
—
EID of the result in the Scopus database
—