Cisplatin electrochemical biosensor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00016155" target="_blank" >RIV/00216224:14310/06:00016155 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/06:00103421
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cisplatin electrochemical biosensor
Original language description
Platinum complexes play an important role in the chemotherapy of various tumour diseases. The aim of this paper was to investigate if a metallothionein (MT) modified hanging mercury drop electrode can be applied as a cisplatin electrochemical biosensor.The modification of the mercury electrode surface by MT and the determination of cisplatin were performed by adsorptive transfer stripping technique and differential pulse voltammetry. The detection limit (3 S/N) of cisplatin ([Pt-II(NH3)(2)Cl-2](0)) calculated from the decrease of CdT peak was about 2.5 pmol in 5 mu l (0.5 mu M) at the interaction time of 400 s. Moreover, we tested the influence of human blood serum as a complex biological matrix on the way of determination of cisplatin. On the basis of the obtained results we estimated that we are able to determine tens of picomoles of cisplatin (5 mu l drop) in the presence of human blood serum.
Czech name
Elektrochemický biosenzor cisplatiny
Czech description
Elektrochemický biosenzor cisplatiny

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Project
<a href="/en/project/GP525%2F04%2FP132" target="_blank" >GP525/04/P132: Study of protection mechanisms for stress-induced by heavy metals</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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