The association between high-activity COMT allele and alcoholism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00016584" target="_blank" >RIV/00216224:14310/06:00016584 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/06:00011022 RIV/00064165:_____/06:00002626

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The association between high-activity COMT allele and alcoholism

Original language description

Objectives: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, andalcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. Methods: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. Results: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p&lt;0,007; and p&lt;0,04 respectively). Conclusions: Our study confirmed the relat

Czech name

Asociace mezi alelou COMT s vysokou aktivitou a alkoholizmem

Czech description

Objevili jsme vztah mezi alelou genu pro COMT, která zanmená vyšší aktivitu COMT a závislostí na alkoholu u mužské části našeho souboru.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR8137" target="_blank" >NR8137: Molecular causes of dispositions to alcoholism.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

231-235

UT code for WoS article

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EID of the result in the Scopus database

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