The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00017435" target="_blank" >RIV/00216224:14310/06:00017435 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The gene for interleukin 6: the candidate gene for neuropsychiatric illness?
Original language description
IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objectivewas to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p<0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p<0.001) between controlsand ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship betw
Czech name
Gen pro interleukin 6: kandidátní gen neuropsychiatrických chorob?
Czech description
IL-6 je kandidátním genem neuropsychiatrických poruch. Nalezli jsme vztah polymorfizmu tohoto genu k ADHD i alkoholizmu. Další studium by mělo tento vztah vyvrátit nebo potvrdit.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NR8137" target="_blank" >NR8137: Molecular causes of dispositions to alcoholism.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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