<I>N</I>-Alkylpurine derivatives as model systems of purine tautomers: Study of substitution effects on solution-state NMR parameters
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00016818" target="_blank" >RIV/00216224:14310/06:00016818 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
<I>N</I>-Alkylpurine derivatives as model systems of purine tautomers: Study of substitution effects on solution-state NMR parameters
Original language description
Purine derivatives as biologically relevant compounds are extensively studied for structure - activity relationships. Specific intermolecular interactions are influenced by electron distribution throughout the purine ring, which is governed by the natureand position of substituents on the purine ring. NMR chemical shifts and indirect spin-spin coupling constants, which represent sensitive probes for detecting the electron density distribution, were compared for a series of purine derivatives. Simultaneously with experimental study, DFT calculations of NMR parameters were carried out. Results of both approaches were examined with an attempt to clarify obtained data on the basis of NBO analysis.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC06030" target="_blank" >LC06030: Biomolecular centre</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů