The mink as an animal model for Pseudomonas aeruginosa adhesion: binding of the bacterial lectins (PA-IL and PA-IIL) to neoglycoproteins and to sections of pancreas and lung tissues from healthy mink

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00020257" target="_blank" >RIV/00216224:14310/07:00020257 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The mink as an animal model for Pseudomonas aeruginosa adhesion: binding of the bacterial lectins (PA-IL and PA-IIL) to neoglycoproteins and to sections of pancreas and lung tissues from healthy mink

Original language description

Lung infection with Pseudomonas aeruginosa, leading to chronic lung disease with impaired function, is the major course of morbidity and mortality among cystic fibrosis patients. The bacterium produces two lectins that bind to a-D-galactose (PA-IL) and L-fucose (PA-IIL), respectively, and lectinecarbohydrate interactions may be involved in microbial pathogenicity by creating bacterial adherence to epithelial and endothelial cells. An ideal animal model for P. aeruginosa infection has until now not beenestablished, but the mink seems to be the only animal that has been reported to develop spontaneous P. aeruginosa infections in the airways. Since cystic fibrosis also severely may affect pancreatic function, we incubated sections from mink lungs and pancreas with a medium containing Pseudomonas lectins in order to detect in situ binding of the bacterial lectins. In the lungs, both lectins adhered to seromucinous glands located in the submucosa of the larger bronchi. Additionally, PA-IL

Czech name

Morče jako živočišný model pro adhezi bakterie Pseudomonas aeruginosa: vazba bakteriálních lektinů (PA-IL a PA-IIL)

Czech description

Morče jako živočišný model pro adhezi bakterie Pseudomonas aeruginosa: vazba bakteriálních lektinů (PA-IL a PA-IIL)

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA303%2F06%2F0570" target="_blank" >GA303/06/0570: Structure-function studies on lectins and adhesins from microbial patogens</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microbes and Infection

ISSN

1286-4579

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

5

Country of publishing house

FR - FRANCE

Number of pages

8

Pages from-to

566-573

UT code for WoS article

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EID of the result in the Scopus database

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