Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00022812" target="_blank" >RIV/00216224:14310/07:00022812 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/07:00087252

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Electrochemical Sensing of Chromium-Induced DNA Damage: DNA Strand Breakage by Intermediates of Chromium(VI) Electrochemical Reduction.

Original language description

DNA damage by CrV and/or CrIV intermediates of CrVI electrochemical reduction was detected using a supercoiled DNA-modified mercury electrode. A signal sensitive to formation of DNA strand breaks, AC voltammetric DNA peak 3, increased due to incubation of the DNA-modified electrode in micromolar solutions of CrVI at potentials sufficiently negative for CrVI reduction. Damage to DNA in solutions containing CrVI and a chemical reductant (ascorbic acid, AA) was observed only at relatively high chromium concentrations (hundreds of M). To eliminate interferences of excess CrVI in measurements of guanine electrochemical signals, a magnetoseparation double surface electrochemical technique was introduced. Using this approach, DNA damage in solution was detected for 50-250 M CrVI upon addition of 1 mM AA. Our results suggest a more efficient DNA damage at the electrode surface due to continuous production of the reactive chromium species, compared to DNA exposure to chromium being reduced chem

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ELECTROANALYSIS

ISSN

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e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

x

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

2093-2102

UT code for WoS article

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EID of the result in the Scopus database

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