Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00041713" target="_blank" >RIV/00216224:14310/07:00041713 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758)
Original language description
The genes of the major histocompatibility complex (MHC) are the most polymorphic loci known for vertebrates. The host- pathogen coevolution and parasite-driven balancing selection have a extensive contribution to the high level of allelic diversity in MHC genes. The polymorphism of MHC molecules can be extremely huge; there are a large number of genetic variants (alleles) at each genetic locus. Individuals with higher number of different MHC molecules are able to recognize a broader spectrum of pathogenor parasite derived antigens, and then pathogens or parasites evolve to evade common MHC genotypes, giving rare MHC genotypes a selective advantage. A common European cyprinid, the chub, Leuciscus cephalus (L.), was chosen as a model organism for investigating the hypothesis of pathogen-driven selection under natural conditions, mediated either through heterozygous advantage (overdominant selection) or negative frequency-dependent selection (rare allele advantage hypothesis).
Czech name
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Czech description
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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