Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00026162" target="_blank" >RIV/00216224:14310/08:00026162 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/08:00005483 RIV/62157124:16370/08:00002017
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine
Original language description
A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2),and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in thecase of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.
Czech name
Syntézy, strukturní charakterizace a antiradikálové a antidiabetické aktivity měďnatých a zinečnatých komplexů Schiff. bazí odvozených od salicylaldehydu and beta-alaninu
Czech description
Byla připravena a fyzikálně-chemickými metodami charakterizována celá série měďnatých a zinečnatých komplexů obsahujících tridentátní O,N,O-donorovou Schiff. bázi odvozenou od salicylaldehydu and beta-alaninu. U všech sloučenin byla studována i jejich antiradikálová a antidiabetická aktivita.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
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Volume of the periodical
102
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
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UT code for WoS article
000255131500001
EID of the result in the Scopus database
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