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Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00026162" target="_blank" >RIV/00216224:14310/08:00026162 - isvavai.cz</a>

  • Alternative codes found

    RIV/61989592:15310/08:00005483 RIV/62157124:16370/08:00002017

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine

  • Original language description

    A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2),and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in thecase of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.

  • Czech name

    Syntézy, strukturní charakterizace a antiradikálové a antidiabetické aktivity měďnatých a zinečnatých komplexů Schiff. bazí odvozených od salicylaldehydu and beta-alaninu

  • Czech description

    Byla připravena a fyzikálně-chemickými metodami charakterizována celá série měďnatých a zinečnatých komplexů obsahujících tridentátní O,N,O-donorovou Schiff. bázi odvozenou od salicylaldehydu and beta-alaninu. U všech sloučenin byla studována i jejich antiradikálová a antidiabetická aktivita.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CA - Inorganic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Inorganic Biochemistry

  • ISSN

    0162-0134

  • e-ISSN

  • Volume of the periodical

    102

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000255131500001

  • EID of the result in the Scopus database