The effects of Eicosanoid biosynthesis inhibitors on oxidative stress, antioxidant response and protein profiles in hemolymph of Galleria mellonella larvae

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00042007" target="_blank" >RIV/00216224:14310/08:00042007 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The effects of Eicosanoid biosynthesis inhibitors on oxidative stress, antioxidant response and protein profiles in hemolymph of Galleria mellonella larvae
Original language description
Effects of eicosanoid biosynthesis inhibitors (EBIs) esculetin, dexamethasone and phenidone on hemolymph concentrations of the oxidative stress indicator malondialdehyde (MDA), antioxidant enzyme (glutathione S-transferase GST) and protein profiles of greater wax moth, Galleria mellonella (L.) seventh instar larvae were investigated. The insects were reared from first instars on artificial diets containing 0.001, 0.01, 0.1 and 1.0 g EBIs per 100 g of diets. MDA content was significantly increased in thepresence of esculetin. Low concentrations of esculetin led to increased GST activity. Dexamethasone at concentrations of 0.001 and 0.01% significantly resulted in increased hemolymph MDA content. However, high dietary dexamethasone concentrations causedsignificant decrease in MDA content while these concentrations resulted in increased GST activity by about three-fold. Dietary phenidone led to increased MDA content and GST activity in the larvae.
Czech name
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Czech description
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Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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