Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00043258" target="_blank" >RIV/00216224:14310/10:00043258 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.
Original language description
We posed the hypothesis that eicosanoids also mediate antioxidant enzymatic defense reactions to pro-oxidant challenge. To test this idea, we reared first-instar larvae of Galleria mellonella (L.) with the lypoxygenase inhibitor, esculetin, the phospholipase A2 inhibitor,dexamethasone and the dual inhibitor of cyclooxygenase and lipoxygenase, phenidone to seventh-instars. Newly ecdysed seventh-instars were then fed on artificial diet containing xanthotoxin (XA) for 2 days. Treating seventh-instar larvaeof G. mellonella with XA induced lipid peroxidation and protein carbonylation as evident from the increased content of malondialdehyde (MDA) and protein carbonyls respectively, and antioxidative enzymatic response in a dose-dependent manner. Relative tocontrol, eicosanoid biosynthesis inhibitors also resulted in impaired MDA content and antioxidant enzyme activities. We infer from these findings that eicosanoids mediate insect antioxidant enzymatic responses to dietary pro-oxidants.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Comparative Biochemistry and Physiology A - Molecular & Integrative Physiology
ISSN
1095-6433
e-ISSN
—
Volume of the periodical
156
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
—
UT code for WoS article
000277748500003
EID of the result in the Scopus database
—