Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00028841" target="_blank" >RIV/00216224:14310/09:00028841 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Procathepsin D mitogenic effect on breast cancer cells is mediated by the NFkB activation
Original language description
Procathepsin D (pCD) is overexpressed and secreted by several types of tumors including breast cancer. pCD affects multiple stages of tumor progression including proliferation, angiogenesis and apoptosis. We have previously shown that mitogenic effect ofpCD on cancer cells is mediated via its propeptide part (AP). However, the mechanism of pCD action on breast cancer cells is not known. In this study we demostrated an increased expression of NFkB luciferase reporter gene, translocation of p65 into cellnucleus, and phosphorylation of IkB in AP-treated MCF-7 breast cancer cells. Moreover, we confirmed that NFkB activity is essential for pro-mitogenic effect of pCD on MCF-7 cells using dominant negative IkB stable transfectants and pharmacological NFkBinhibitors. These results suggest that pharmacological inhibitors of NFkB may be useful for treatment of pCD-secreting tumors.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů