Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00034796" target="_blank" >RIV/00216224:14310/09:00034796 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

Original language description

Activation of FGFR3 leads to attenutation of cartilage growth. We evidence that FGF stimulus leads to accumulation of STAT1, 3, 5, 6 both in chondrocyte model and murine limb explant cultures. Despite this accummulation, STAT 1, and 3 signaling pathwaysare impaired by FGF. FGF increases also expression of CIS, SOCS1, and SOCS3, inhibitors of IL6 receptor signaling and thus may contribute to the growth-inhibitory effect of FGFR3 signaling in cartilage.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cellular Signalling

ISSN

0898-6568

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000262060900019

EID of the result in the Scopus database

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