Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00037410" target="_blank" >RIV/00216224:14310/09:00037410 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates

Original language description

Two DO3A-based ligands appended with the propylphosphonate side arm and their Ln3+ complexes were investigated. Proton relaxometric in vitro studies at 20 MHz and 60 MHz and 37 degree of Celsius of the Gd3+ complex containing free acid exhibited relativechanges of up to 56 % in r1 relaxivity when the pH of the medium was changed from 4 to 7. This change is explained by the decrease in the number of coordinated water molecules from two to one. Temperature-dependent relaxivity and NMRD profiles of Gd3+ complexes showed a fast water exchange and a slightly increased rotational correlation time, which is characteristic of phosphonate-containing compounds. Thermodynamic and kinetic studies of the Gd3+ and Eu3+ complexes were performed by means of potentiometry and luminescence spectroscopy. The results indicate that the thermodynamic stability and kinetic inertness of these complexes are sufficient for their in vivo application.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

<a href="/en/project/OC%20179" target="_blank" >OC 179: Metal-based systems for molecular imaging applications</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Eur. J. Inorg. Chem.

ISSN

1434-1948

e-ISSN

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Volume of the periodical

2009

Issue of the periodical within the volume

22

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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