Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00042953" target="_blank" >RIV/00216224:14310/09:00042953 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Thermodynamic and kinetic study of copper(II) complexes with monophosphorus acid DOTA derivatives
Original language description
Bifunctional chelating agents (BFC) complexing copper(II) ion are utilized in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). BFC contain metal coordination unit (e.g. macrocycle) attached to biologically activemolecules. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Therefore, it is necessary to know thermodynamic and kinetic properties (dissociation rate constants for estimation ofkinetic inertness) of copper(II) complexes in order to find the best macrocyclic BFC for possible medical applications in vivo. In this work, the thermodynamic and kinetic properties of copper(II) complexes with macrocyclic ligands with acetic and phosphorus acid pendant arms were studied.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ME09065" target="_blank" >ME09065: Research of new detection systems based on sensor arrays for application in speciation analysis</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů