Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040583" target="_blank" >RIV/00216224:14310/10:00040583 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Original language description
Wedelolactone is an active polyphenolic coumestan isolated from the plant extracts of Wedelia chinensis and Eclipta prostrata. Recently, wedelolactone has been shown to reduce growth cancer cells. These effects were attributed to the inhibition of NFkB and androgen receptors. In this study, we tested the effect of wedelolactone on proliferation, differentiation and apoptosis of breast cancer MDA-MB-231 cells. Wedelolactone in uM concentrations suppresses growth of MDA-MB-231 cells by blocking cell cycleprogression in the S- and G2/M phases. The 10 uM wedelolactone induces cell differentiation and the 30 uM wedelolactone reduces viability and induces apoptosis of MDA-MB-231 cells. We found that the growth inhibitory and proapoptotic effects of wedelolactone do not result from deregulation of NFkB activity but they are more likely to be attributed to its ability to bind dsDNA, to inhibit topoisomerase IIa and to induce DNA damage.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů