Inhibition of topoisomerase IIa: Novel function of wedelolactone
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00049412" target="_blank" >RIV/00216224:14310/11:00049412 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0304383511000127" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0304383511000127</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.canlet.2011.01.002" target="_blank" >10.1016/j.canlet.2011.01.002</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of topoisomerase IIa: Novel function of wedelolactone
Original language description
The naturally occurring coumestan wedelolactone has been previously shown to reduce growth of various cancer cells. So far, the growth-suppressing effect of wedelolactone has been attributed to the inhibition of the NFkB transcription factor and/or androgen receptors. We found that wedelolactone suppressed growth and induced apoptosis of androgen receptor-negative MDA-MB-231 breast cancer cells at concentrations that did not inhibit the NFkB activity. The cells responded to wedelolactone by the S and G2/M phase cell cycle arrest and induction of the DNA damage signaling. Wedelolactone interacted with dsDNA and inhibited the activity of DNA topoisomerase IIa. We conclude that wedelolactone can act as growth suppressor independently of NFkB and androgenreceptors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Letters
ISSN
0304-3835
e-ISSN
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Volume of the periodical
303
Issue of the periodical within the volume
1
Country of publishing house
IE - IRELAND
Number of pages
10
Pages from-to
29-38
UT code for WoS article
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EID of the result in the Scopus database
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