b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00040591" target="_blank" >RIV/00216224:14310/10:00040591 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Original language description

Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptorsof the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Pharmacology

ISSN

1476-5381

e-ISSN

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Volume of the periodical

159

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

000275402000007

EID of the result in the Scopus database

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