Preparation of microsamples for elemental analysis of biological samples
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00043578" target="_blank" >RIV/00216224:14310/10:00043578 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preparation of microsamples for elemental analysis of biological samples
Original language description
New approaches of sample introduction to inductively-coupled plasma mass spectrometry which are especially suitable for minute amount of samples are presented. Detailed characterization of SALD ICP MS has shown large signal stability over a wide range oflaser power density values, the independence of signal on acquisition modes and linear dynamic range over six orders of magnitude. SALD ICP MS with low limits of detection (0.1-14 fmol for Cr, Cu, Co, Fe, Ni, Sn and Zn) is suitable for off-line couplingwith capillary electrophoresis (CE) for speciation analysis or selective detection of metals. Applicability to biological samples analysis was demonstrated on investigation of the role of copper ions to regulate cytotoxicity of disulfiram in myeloid leukemia cells. SALD ICP MS allows rapid, sensitive and reproducible method for quantitative analysis of metals with very low consumption of sample.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F09%2F1025" target="_blank" >GA203/09/1025: Multidetection platform for microcolumn separation of proteins and peptides</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
25th International Symposium on MicroScale Bioseparations MSB 2010
ISBN
978-80-254-6631-5
ISSN
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e-ISSN
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Number of pages
2
Pages from-to
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Publisher name
IACh AS CR, v.v.i.
Place of publication
Brno
Event location
Praha
Event date
Jan 1, 2010
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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