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Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in Czech Republic

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044089" target="_blank" >RIV/00216224:14310/10:00044089 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in Czech Republic

  • Original language description

    We have isolated and characterized two distinct types of exfoliative toxin A (ETA) converting bacteriophages originated from the S. aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as phiB531, phiB557 and phiB122, were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain, and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phiB531 and phiB557 were identical each other, but phiB122 differed from them in five gene sequences, the xis gene content, and virion protein profile. Thus, phiB122 represents a new type of still undescribed ETA converting phage. This study has highlighted not only the conclusive genomic diversity of eta gene-positive phages but also their virulence implications in impetigo S. aureus strains.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA310%2F09%2F0459" target="_blank" >GA310/09/0459: Role of bacteriophages in horizontal transfer of virulence and drug resistance genes in Staphylococcus aureus</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>R - Projekt Ramcoveho programu EK<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Research in Microbiology

  • ISSN

    0923-2508

  • e-ISSN

  • Volume of the periodical

    161

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    000279125600003

  • EID of the result in the Scopus database