Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080938" target="_blank" >RIV/00216224:14310/15:00080938 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/15:#0001295 RIV/75010330:_____/15:00010928
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs11262-015-1223-8" target="_blank" >http://link.springer.com/article/10.1007%2Fs11262-015-1223-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11262-015-1223-8" target="_blank" >10.1007/s11262-015-1223-8</a>

Result language
angličtina
Original language name
Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus
Original language description
Exfoliative toxin A (ETA)-coding temperate bacteriophages are leading contributors to the toxic phenotype of impetigo strains of Staphylococcus aureus. Two distinct eta gene-positive bacteriophages isolated from S. aureus strains which recently caused massive outbreaks of pemphigus neonatorum in Czech maternity hospitals were characterized. The phages, designated B166 and B236, were able to transfer the eta gene into a prophageless S. aureus strain which afterwards converted into an ETA producer. Complete phage genome sequences were determined, and a comparative analysis of five designed genomic regions revealed major variances between them. They differed in the genome size, number of open reading frames, genome architecture, and virion protein patterns. Their high mutual sequence similarity was detected only in the terminal regions of the genome. When compared with the so far described eta phage genomes, noticeable differences were found.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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