Cytotoxic Activities of Several Geranyl-Substituted Flavanones
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F10%3A00044352" target="_blank" >RIV/00216224:14310/10:00044352 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/10:00349184 RIV/61989592:15310/10:10213445 RIV/62157124:16370/10:00002620 RIV/60461373:22340/10:00023392
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cytotoxic Activities of Several Geranyl-Substituted Flavanones
Original language description
Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using acalcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin, naringenin, and hesperetin and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranylsubstitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Natural Products
ISSN
0163-3864
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
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UT code for WoS article
000276950000011
EID of the result in the Scopus database
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